Peazan is an analgesic and anti-inflammatory drug by Aquaviva Nutrifarma

ANALGESIC AND ANTI-INFLAMMATORY
30 capsules

Indications for use:
• chronic pain with compression syndrome;
• neuropathic pain;
• disorders of the intervertebral discs;
• muscle pains.

Storage:
palmitoylethanolamide, dry extract of Sichuan pepper (Zanthoxylum bungeanum Maxim., fruit), glazing agent: hydroxypropylmethylcellulose, anti-caking agent: silicon dioxide, magnesium salts of fatty acids; thiamine
hydrochloride (vitamin B1), pyridoxine hydrochloride (vitamin B6), cyanocobalamin (vitamin B12).

Application method:
take 1 capsule per day with a glass of water. The duration of treatment depends on the intensity of the pain. It can be used both once and for a long time.

PEA: ANALGESIC EFFECT IN COMPRESSION NEUROPATHIES SUCH AS LUMBOISHIALGIA AND DISCOPATHY
Palmitoylethanolamide (PEA) is a derivative of palmitic acid, and its presence in tissues is associated with a reduction in inflammatory processes. In nature, molecules of this type (PEA) belong to
to the class of intracellular signaling molecules. They participate in the regulation of the inflammatory process and pain sensations. With any inflammation, cells of the immune system, malignant and glial cells are activated.
As a result, a large number of inflammatory mediators are released, which contributes to the development and preservation of the pain syndrome. PEA acts on mast cells and glia as an anti-inflammatory mediator and, stopping inflammation, reduces it
pain syndrome

PEA acts in various ways, in particular with mediators of other regulatory systems, which has received the name "synergy effect" (entourage effect).
• Has a direct analgesic effect.
• Enhances the activity of anandamide (a mediator of the endocannabinoid system) and its effect on analgesic receptors CB2 - CB1 and TRP-V1.
• Suppresses the production of inflammatory cytokines through the activation of PPARα and PPARϒ in microglia.
• Blocks local damage caused by mast cell pro-inflammatory mediators.

The molecular structure of PEA is very similar to endocannabinoids, endogenous physiological mediators that are released in damaged tissues to reduce pain. PEA, contacting
by the cannabinoid receptor or substituting as a substrate for the enzyme that destroys them (FAAH), provides an analgesic effect by interrupting the onset and propagation of pain.

Szechuan PEPPER: HAS ANTI-INFLAMMATORY ACTIVITY AND IS A SODIUM CHANNEL BLOCKER
A traditional plant of Asian medicine, the highly purified extract of which is obtained from the peel of the fruit. In recent years, numerous studies have been conducted on the therapeutic potential of Sichuan pepper. The main pharmacological action is anti-inflammatory and analgesic. The first is achieved by influencing the physicochemical process of the release of inflammatory cytokines, and by influencing the neurotrophic factor BDNF, central relief of chronic pain is achieved.

VITAMINS B1, B6, B12: RESTORATION OF NERVE CELL FUNCTIONS
B vitamins, especially B1, B6 and B12, play an important role in many cellular enzymatic reactions, especially in the processes of energy production (Krebs cycle), protein synthesis, which is useful for cell renewal and repair, neurotransmitter exchange and nerve impulse transmission.